| Romance of the Three Kingdoms IV: Wall of Fire | WII | E | | Mar 26, 2007 | Koei |
| Rusty's Real Deal Baseball | 3DS | E | 74 | Apr 3, 2014 | Nintendo |
| Sakura Samurai: Art of the Sword | 3DS | T | 74 | Feb 2, 2012 | Grounding Inc. |
| Samurai Warriors 3 | WII | T | 55 | Sep 28, 2010 | Omega Force |
| Seasons of Heaven | Switch | | | TBA | AnyArts Productions |
| Shining in the Darkness | WII | E | | Aug 13, 2007 | Climax Entertainment |
| Shockman | WII | E | | Apr 30, 2007 | Winds |
| SimCity | WII | E | | Nov 19, 2006 | Maxis |
| Sin & Punishment: Star Successor | WII | T | 87 | Jun 27, 2010 | Treasure |
| Sin and Punishment | WII | T | | Oct 1, 2007 | Treasure |
| Sine Mora EX | Switch | M | 70 | Aug 8, 2017 | Grasshopper Manufacture |
| SiNG Party | WIIU | E10+ | 60 | Nov 18, 2012 | FreeStyleGames |
| Smash Controller | 3DS | | | Jun 14, 2015 | Nintendo |
| Snapdots | DS | E | | Oct 18, 2010 | D4 Enterprise |
| Snipperclips - Cut it out, together! | Switch | E | 80 | Mar 3, 2017 | Nintendo & SFB Games |
| Snipperclips Plus: Cut It Out, Together! | Switch | E | 84 | Nov 10, 2017 | SFB Games |
| Snowpack Park | WII | E | | Nov 22, 2010 | Skip Ltd. |
| Soccer | WII | E | | Nov 19, 2006 | Nintendo |
| Sparkle Snapshots | DS | | | Nov 2, 2009 | Nintendo & Atlus |
| Sparkle Snapshots 3D | 3DS | | 67 | Oct 18, 2012 | Atlus Co. & Atlus |